abstract：:Vitamin K antagonists were the only class of oral anticoagulants available to clinicians for decades. However, with the US Food and Drug Administration approval of new oral anticoagulants, such as dabigatran, rivaroxaban, and apixaban, clinicians now have a broader choice. Given the recent approval and availability of...

journal_title：Mayo Clinic proceedings

authors： Gonsalves WI,Pruthi RK,Patnaik MM

更新日期：2013-05-01 00:00:00

abstract：OBJECTIVE:To determine whether the use of a computerized bar code-based blood identification system resulted in a reduction in transfusion errors or near-miss transfusion episodes. PATIENTS AND METHODS:Our institution instituted a computerized bar code-based blood identification system in October 2006. After instituti...

journal_title：Mayo Clinic proceedings

authors： Nuttall GA,Abenstein JP,Stubbs JR,Santrach P,Ereth MH,Johnson PM,Douglas E,Oliver WC Jr

更新日期：2013-04-01 00:00:00

abstract：OBJECTIVE:To provide a practical formula for fresh frozen plasma (FFP) dosing for warfarin reversal. PATIENTS AND METHODS:We reviewed data on all adult patients who received a total of 7778 units of FFP for warfarin reversal at Sentara Norfolk General Hospital (Norfolk, VA) between April 1, 2009, and March 31, 2010. P...

journal_title：Mayo Clinic proceedings

authors： Rashidi A,Tahhan HR

更新日期：2013-03-01 00:00:00

abstract：OBJECTIVE:To assess the efficacy and safety of hyperbaric oxygenation (HBO) therapy as adjunctive treatment for diabetic foot ulcers with a systematic review and meta-analysis of the literature. METHODS:MEDLINE, EMBASE, and the Cochrane Library were searched to find relevant articles published up to April 20, 2012, wi...

journal_title：Mayo Clinic proceedings

authors： Liu R,Li L,Yang M,Boden G,Yang G

更新日期：2013-02-01 00:00:00

abstract：:An interactive audio and video telemedicine feasibility program was established to provide counseling on breast cancer risk-reducing strategies for underserved, high-risk Alaskan native women through a collaboration among the Alaska Native Medical Center, the Mayo Clinic Breast Clinic, Mayo's Center for Innovation, an...

journal_title：Mayo Clinic proceedings

authors： Pruthi S,Stange KJ,Malagrino GD Jr,Chawla KS,LaRusso NF,Kaur JS

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:To analyze the relationship of ideal cardiovascular health to disease-specific death. PATIENTS AND METHODS:We used data from the Aerobics Center Longitudinal Study from October 9, 1987, to March 3, 1999, to estimate the prevalence of ideal cardiovascular health in 11,993 individuals (24.3% women) and to exam...

journal_title：Mayo Clinic proceedings

authors： Artero EG,España-Romero V,Lee DC,Sui X,Church TS,Lavie CJ,Blair SN

更新日期：2012-10-01 00:00:00

abstract：OBJECTIVE:To prospectively assess the safety and effectiveness of the investigational phosphodiesterase 5 inhibitor avanafil to treat erectile dysfunction in men with diabetes mellitus. PATIENTS AND METHODS:This 12-week, multicenter, double-blind, placebo-controlled study conducted between December 15, 2008, and Febru...

journal_title：Mayo Clinic proceedings

authors： Goldstein I,Jones LA,Belkoff LH,Karlin GS,Bowden CH,Peterson CA,Trask BA,Day WW

更新日期：2012-09-01 00:00:00

abstract：OBJECTIVE:To evaluate the rate of and potential risk factors for bloodstream infections (BSIs) using data from the REVEAL (Registry to Evaluate Early and Long-term Pulmonary Arterial Hypertension [PAH] Disease Management) REGISTRY(®), which provides current information about patients with PAH. PATIENTS AND METHODS:Pat...

journal_title：Mayo Clinic proceedings

authors： Kitterman N,Poms A,Miller DP,Lombardi S,Farber HW,Barst RJ

更新日期：2012-09-01 00:00:00

abstract：OBJECTIVES:To describe the development and implementation process and assess the effect on self-reported clinical practice changes of a multidisciplinary, collaborative, interactive continuing medical education (CME)/continuing education (CE) program on chronic obstructive pulmonary disease (COPD). METHODS:Multidiscip...

journal_title：Mayo Clinic proceedings

authors： Adams SG,Pitts J,Wynne J,Yawn BP,Diamond EJ,Lee S,Dellert E,Hanania NA

更新日期：2012-09-01 00:00:00

abstract：:The evaluation of the patient with diarrhea can be complex and the treatment challenging. In this article, the definition of diarrhea and the pathophysiologic mechanisms that lead to diarrhea are reviewed. A simplified 5-step approach to the patient with diarrhea is provided and applied in a case-oriented manner appli...

journal_title：Mayo Clinic proceedings

authors： Sweetser S

更新日期：2012-06-01 00:00:00

abstract：:Despite the emergence of clinical ethics consultation as a clinical service in recent years, little is known about how clinical ethics consultation differs from, or is the same as, other medical consultations. A critical assessment of the similarities and differences between these 2 types of consultations is important...

journal_title：Mayo Clinic proceedings

authors： Geppert CM,Shelton WN

更新日期：2012-04-01 00:00:00

abstract：OBJECTIVE:To evaluate the role of cardiac troponin T (cTnT) in predicting death, recurrent ischemic events, and heart failure among community-dwelling persons with first myocardial infarction (MI). PATIENTS AND METHODS:Consecutive Olmsted County, Minnesota, residents with an incident MI between November 6, 2002, and D...

journal_title：Mayo Clinic proceedings

authors： Gerber Y,Jaffe AS,Weston SA,Jiang R,Roger VL

更新日期：2012-03-01 00:00:00

abstract：:Nonrelaxing pelvic floor dysfunction is not widely recognized. Unlike in pelvic floor disorders caused by relaxed muscles (eg, pelvic organ prolapse or urinary incontinence, both of which often are identified readily), women affected by nonrelaxing pelvic floor dysfunction may present with a broad range of nonspecific...

journal_title：Mayo Clinic proceedings

authors： Faubion SS,Shuster LT,Bharucha AE

更新日期：2012-02-01 00:00:00

abstract：OBJECTIVE:To estimate cancer risks for patients with myotonic dystrophy, given that increased risks for neoplasms in association with myotonic dystrophy type 1 and type 2 have been suggested in several studies but the risks of cancers have not been quantified. PATIENTS AND METHODS:A cohort of 307 patients with myotoni...

journal_title：Mayo Clinic proceedings

authors： Win AK,Perattur PG,Pulido JS,Pulido CM,Lindor NM

更新日期：2012-02-01 00:00:00

abstract：:Treatment of seniors with Parkinson disease is within the domain of primary care physicians and internists. A good working knowledge of carbidopa/levodopa principles should allow excellent care of most patients, at least during the early years of the disease. Even later, when levodopa responses become more complicated...

journal_title：Mayo Clinic proceedings

authors： Ahlskog JE

更新日期：2011-12-01 00:00:00

abstract：OBJECTIVE:To determine the risk of hospitalization and death in relation to preexisting depression and anxiety among patients with cardiovascular disease (CVD). PATIENTS AND METHODS:The cohort consisted of 799 Olmsted County, MN, residents diagnosed with CVD (myocardial infarction or heart failure) from January 1, 197...

journal_title：Mayo Clinic proceedings

authors： Chamberlain AM,Vickers KS,Colligan RC,Weston SA,Rummans TA,Roger VL

更新日期：2011-11-01 00:00:00

abstract：OBJECTIVE:To assess the impact of direct-to-consumer (DTC) predictive genomic risk information on perceived risk and worry in the context of routine clinical care. PATIENTS AND METHODS:Patients attending a preventive medicine clinic between June 1 and December 18, 2009, were randomly assigned to receive either genomic...

journal_title：Mayo Clinic proceedings

authors： James KM,Cowl CT,Tilburt JC,Sinicrope PS,Robinson ME,Frimannsdottir KR,Tiedje K,Koenig BA

更新日期：2011-10-01 00:00:00

abstract：:A rapidly growing literature strongly suggests that exercise, specifically aerobic exercise, may attenuate cognitive impairment and reduce dementia risk. We used PubMed (keywords exercise and cognition) and manuscript bibliographies to examine the published evidence of a cognitive neuroprotective effect of exercise. M...

journal_title：Mayo Clinic proceedings

authors： Ahlskog JE,Geda YE,Graff-Radford NR,Petersen RC

更新日期：2011-09-01 00:00:00

abstract：:For over a decade, the field of stem cell research has advanced tremendously and gained new attention in light of novel insights and emerging developments for regenerative medicine. Invariably, multiple considerations come into play, and clinicians and researchers must weigh the benefits of certain stem cell platforms...

journal_title：Mayo Clinic proceedings

authors： Zacharias DG,Nelson TJ,Mueller PS,Hook CC

更新日期：2011-07-01 00:00:00

abstract：:A 54-year-old man with no known cardiac disease collapsed outdoors in a small rural community. The cardiac arrest was witnessed, and immediate cardiopulmonary resuscitation was begun by a bystander and a trained first responder who was nearby. The patient was moved into a building across the street for continued resus...

journal_title：Mayo Clinic proceedings

authors： White RD,Goodman BW,Svoboda MA

更新日期：2011-06-01 00:00:00

abstract：:Parasitic diseases affect more than 2 billion people globally and cause substantial morbidity and mortality, particularly among the world's poorest people. This overview focuses on the treatment of the major protozoan and helminth infections in humans. Recent developments in antiparasitic therapy include the expansion...

journal_title：Mayo Clinic proceedings

authors： Kappagoda S,Singh U,Blackburn BG

更新日期：2011-06-01 00:00:00

abstract：OBJECTIVE:To estimate the prevalence of unidentified chronic obstructive pulmonary disease (COPD) and determine the screening accuracy of the Lung Function Questionnaire (LFQ). PATIENTS AND METHODS:Cigarette smokers who had a smoking history of 10 or more pack-years and were aged 30 years or older were recruited from ...

journal_title：Mayo Clinic proceedings

authors： Mintz ML,Yawn BP,Mannino DM,Donohue JF,Hanania NA,Grellet CA,Gilsenan AW,McLeod LD,Dalal AA,Raphiou IH,Prillaman BA,Crater GD,Cicale MJ,Mapel DW

更新日期：2011-05-01 00:00:00

abstract：:The treatment of chronic illnesses commonly includes the long-term use of pharmacotherapy. Although these medications are effective in combating disease, their full benefits are often not realized because approximately 50% of patients do not take their medications as prescribed. Factors contributing to poor medication...

journal_title：Mayo Clinic proceedings

authors： Brown MT,Bussell JK

更新日期：2011-04-01 00:00:00

abstract：OBJECTIVE:To measure the effect of duty periods no longer than 16 hours on patient care and resident education. PATIENTS AND METHODS:As part of our Educational Innovations Project, we piloted a novel resident schedule for an inpatient service that eliminated shifts longer than 16 hours without increased staffing or de...

journal_title：Mayo Clinic proceedings

authors： McCoy CP,Halvorsen AJ,Loftus CG,McDonald FS,Oxentenko AS

更新日期：2011-03-01 00:00:00

abstract：:Type 2 diabetes mellitus (DM) is a major cardiovascular (CV) risk factor and, as such, is considered a coronary artery disease risk equivalent. Although glycemic control is associated with decreased CV events epidemiologically, many prospective clinical trials have failed to conclusively demonstrate that aggressive gl...

journal_title：Mayo Clinic proceedings

authors： O'Keefe JH,Abuannadi M,Lavie CJ,Bell DS

更新日期：2011-02-01 00:00:00

abstract：OBJECTIVE:To examine whether the outcome of patients with primary systemic amyloidosis (AL) has improved over time and to identify predictors of early mortality in patients with AL. PATIENTS AND METHODS:We studied 2 separate cohorts of patients. The first cohort, consisting of 1998 patients with AL seen at Mayo Clinic...

journal_title：Mayo Clinic proceedings

authors： Kumar SK,Gertz MA,Lacy MQ,Dingli D,Hayman SR,Buadi FK,Short-Detweiler K,Zeldenrust SR,Leung N,Greipp PR,Lust JA,Russell SJ,Kyle RA,Rajkumar SV,Dispenzieri A

更新日期：2011-01-01 00:00:00

abstract：:Nine patients treated with primary signet ring cell carcinoma of the prostate were identified among 29,783 cases of prostate cancer evaluated at Mayo Clinic from January 15, 1970, until January 2, 2009. A PubMed search of the English-language literature published from January 1, 1980, to January 1, 2010, was then perf...

journal_title：Mayo Clinic proceedings

authors： Warner JN,Nakamura LY,Pacelli A,Humphreys MR,Castle EP

更新日期：2010-12-01 00:00:00

abstract：:Waldenström macroglobulinemia is a B-cell malignancy with lymphoplasmacytic infiltration in the bone marrow or lymphatic tissue and a monoclonal immunoglobulin M protein (IgM) in the serum. It is incurable with current therapy, and the decision to treat patients as well as the choice of treatment can be complex. Using...

journal_title：Mayo Clinic proceedings

authors： Ansell SM,Kyle RA,Reeder CB,Fonseca R,Mikhael JR,Morice WG,Bergsagel PL,Buadi FK,Colgan JP,Dingli D,Dispenzieri A,Greipp PR,Habermann TM,Hayman SR,Inwards DJ,Johnston PB,Kumar SK,Lacy MQ,Lust JA,Markovic SN,Micall

更新日期：2010-09-01 00:00:00

abstract：OBJECTIVE:To describe the history, objectives, statistics, and initiatives used to address challenges associated with the Mayo Clinic Visiting Medical Student (VMS) Clerkship Program. MATERIALS AND METHODS:Mayo Clinic administrative records were reviewed for calendar years 1995 through 2008 to determine the effect of ...

journal_title：Mayo Clinic proceedings

authors： Mueller PS,McConahey LL,Orvidas LJ,Jenkins SM,Kasten MJ

更新日期：2010-08-01 00:00:00

abstract：:Intraoperative (IO) transesophageal echocardiography (TEE) is widely used for assessing the results of valvular heart disease (VHD) surgery. Epiaortic ultrasonography (EAU) has been recommended for prevention of perioperative strokes. To what extent does high-quality evidence justify the widespread use of these imagin...

journal_title：Mayo Clinic proceedings

authors： Michelena HI,Abel MD,Suri RM,Freeman WK,Click RL,Sundt TM,Schaff HV,Enriquez-Sarano M

更新日期：2010-07-01 00:00:00

abstract：OBJECTIVE:To define age-adjusted incidence trends in multiple myeloma (MM) in a well-characterized population during a long period, given that some, but not all, studies have reported increasing MM incidence over time and that clinical experience from some centers suggests an increased incidence mainly in younger age g...

journal_title：Mayo Clinic proceedings

authors： Turesson I,Velez R,Kristinsson SY,Landgren O

更新日期：2010-03-01 00:00:00

abstract：OBJECTIVE:To explore the influence of referral bias on complication rates after vaginal hysterectomy. PATIENTS AND METHODS:Community-based (local) and referral patients had benign indications and underwent vaginal hysterectomy from January 1, 2004, through December 31, 2005. We retrospectively evaluated patient charac...

journal_title：Mayo Clinic proceedings

authors： Heisler CA,Melton LJ 3rd,Weaver AL,Gebhart JB

更新日期：2010-02-01 00:00:00

abstract：OBJECTIVE:To evaluate the effect of prior duration of diabetes, glycated hemoglobin level at study entry, and microalbuminuria or macroalbuminuria on the extent and severity of coronary artery disease (CAD) and peripheral arterial disease. PATIENTS AND METHODS:We studied baseline characteristics of the 2368 participan...

journal_title：Mayo Clinic proceedings

authors： Escobedo J,Rana JS,Lombardero MS,Albert SG,Davis AM,Kennedy FP,Mooradian AD,Robertson DG,Srinivas VS,Gebhart SS,BARI 2D Study Group.

更新日期：2010-01-01 00:00:00

abstract：:Coronary artery disease (CAD) is the single most common cause of death in the developed world, responsible for about 1 in every 5 deaths. The morbidity, mortality, and socioeconomic importance of this disease make timely accurate diagnosis and cost-effective management of CAD of the utmost importance. This comprehensi...

journal_title：Mayo Clinic proceedings

authors： Cassar A,Holmes DR Jr,Rihal CS,Gersh BJ

更新日期：2009-12-01 00:00:00

abstract：:Myocarditis, an inflammatory disease of heart muscle, is an important cause of dilated cardiomyopathy worldwide. Viral infection is also an important cause of myocarditis, and the spectrum of viruses known to cause myocarditis has changed in the past 2 decades. Several new diagnostic methods, such as cardiac magnetic ...

journal_title：Mayo Clinic proceedings

authors： Schultz JC,Hilliard AA,Cooper LT Jr,Rihal CS

更新日期：2009-11-01 00:00:00

abstract：:The sympathetic nervous system plays a key role in regulating arterial blood pressure in humans. This review provides an overview of sympathetic neural control of the circulation and discusses the changes that occur in various disease states, including hypertension, heart failure, and obstructive sleep apnea. It focus...

journal_title：Mayo Clinic proceedings

authors： Charkoudian N,Rabbitts JA

更新日期：2009-09-01 00:00:00

abstract：:Cigarette smoking is the most important preventable cause of morbidity, mortality, and excess health care costs in the United States. From 2000 through 2004, cigarette smoking caused an estimated annual average of 443,595 deaths and cost $193 billion per year in smoking-attributable productivity losses and smoking-rel...

journal_title：Mayo Clinic proceedings

authors： Hays JT,Ebbert JO,Sood A

更新日期：2009-08-01 00:00:00

abstract：:Breast cancer is the most common noncutaneous malignancy among every major ethnic group of women in the United States. Anthracyclines and taxanes are the most active and widely used chemotherapeutic agents for breast cancer, but the increased use of these agents at an early stage of disease often renders tumors resist...

journal_title：Mayo Clinic proceedings

authors： Moreno-Aspitia A,Perez EA

更新日期：2009-06-01 00:00:00

abstract：:Evidence suggests that migraine is associated with decreased productivity. This article describes the results of a systematic literature review of peer-reviewed publications that measured the impact of migraine on workplace productivity in the United States and provides recommendations for future research. A MEDLINE s...

journal_title：Mayo Clinic proceedings

authors： Burton WN,Landy SH,Downs KE,Runken MC

更新日期：2009-05-01 00:00:00

abstract：OBJECTIVE:To determine whether sirolimus therapy is associated with neurologic complications, including stroke, among heart transplant recipients. PATIENTS AND METHODS:We retrospectively studied patients who underwent heart transplant at Mayo Clinic's site in Rochester, MN, from January 1, 1988, through June 30, 2006....

journal_title：Mayo Clinic proceedings

authors： van de Beek D,Kremers WK,Kushwaha SS,McGregor CG,Wijdicks EF

更新日期：2009-04-01 00:00:00